美国阿拉巴马大学伯明翰分校DrJarredYounger实验室招聘博后负责项目撰写和申请等

The Neuroinflammation, Pain and Fatigue Laboratory, under the direction of Dr. Jarred Younger, is seeking a postdoctoral fellow to head scientific writing of several completed and ongoing human projects. The fellow will work closely with the Principal Investigator to produce manuscripts and grant applications, and will have the opportunity to assume first-author position on manuscripts.

While this position is available as a traditional postdoctoral fellowship, candidates with very strong communication skills can also be considered for a remote-work position based within the United States.

An advanced research or clinical degree is required for this position. Individuals may have a PhD in Psychology, Immunology, Pharmacology, or related fields. Individuals with an MD, DO, ND, or other advanced clinical degree are also eligible to apply. Applicants must have a demonstrated track record of being primary author on peer-reviewed scientific publications and must have excellent overall scientific writing skills. A background in inflammation, immunology, clinical trials, and human experimental research is helpful, but not required. 

The laboratory is funded through NIH, DoD, and non-profit sources. We focus on developing new diagnostic techniques and treatments for chronic pain and fatigue conditions. Our primary laboratory techniques include clinical trials of pharmaceutical and botanical treatments, observational analyses of inflammatory disease mediators, experimental immune provocations with endotoxin and other agents, and neuroimaging (MRI and PET). We emphasize the exploration of inflammatory and neuroinflammatory causes of chronic diseases such as fibromyalgia and chronic fatigue syndrome. More information about the laboratory can be found at:  YouTube: https://goo.gl/S1wFyg; Facebook: https://goo.gl/VyDTQE; Website: https://cas.uab.edu/younger/

This is a full-time position with an initial appointment letter for one year with additional years contingent on satisfactory performance and available funding. The start date is negotiable, but would preferably occur in Fall of 2018.

To apply, please submit a cover letter and a CV to youngerlab@uab.edu

Jarred Younger, PhD

Director and Associate Professor

Email: youngerlab@uab.edu

Jarred Younger received his Ph.D. in Experimental Psychophysiology in 2003 at the University of Tennessee, Knoxville. He then completed postdoctoral fellowships at Arizona State University and the Stanford University School of Medicine before taking an assistant professor position at Stanford. In 2014, he joined the faculty at the University of Alabama Birmingham, with a primary appointment in the Department of Psychology and secondary appointments in the Departments of Anesthesiology and Rheumatology. Prof. Younger’s goal is to end the chronic pain and fatigue that is caused by inflammation in the brain. He is currently funded by the National Institutes of Health, Department of Defense, and several non-profit agencies to develop techniques for diagnosing and treating neuroinflammation, pain, and fatigue.

Current Projects

Discovering the source of chronic pain and fatigue

We have found specific chemicals in the blood that may cause chronic pain and fatigue in many women. These chemicals are part of an immune system that may not be working correctly. We have received funding from the National Institutes of Health to continue testing the role of these chemicals in disease. If we are successful, we may not only produce an objective test of fibromyalgia and myalgic encephalomyelitis, also known as chronic fatigue syndrome, but we may also be able to develop more effective treatments for those disorders. Women participating in this study have blood draws over multiple days and record their symptoms on a handheld computer.

Daily immune monitoring in men with Gulf War Illness

After the 1991 Gulf War, many individuals in the military returned home with a range of unexplained symptoms. Most of those individuals experience chronic pain and/or fatigue. We believe that environmental exposures while in the Persian Gulf region may have sensitized the immune system, causing the symptoms of Gulf War illness. We are testing that hypothesis by measuring several inflammatory chemicals in the blood of people who suffer from the condition. Our goal is to learn more about Gulf War illness so we can develop effective and safe treatments.

Using botanical anti-inflammatories to treat Gulf War Illness

We now know that several botanical agents, such as mushrooms, nettles, and herbs, have anti-inflammatory properties that may benefit individuals with chronic pain or fatigue. Most of these products are available without a prescription, but they have never been tested in Gulf War illness. We are currently funded by the Department of Defense to test some of these supplements in individuals with Gulf War illness. If these anti-inflammatory products reduce symptoms, then we will learn more about what is wrong in people with Gulf War illness and make progress in treatments that make patients function and feel better.

Developing better methods for detecting inflammation in the brain

We believe that low-level inflammation in the brain may be the cause of many cases of pain, fatigue, problems with thinking or memory, and depression. Unfortunately, no tool is currently available that allows us to determine if someone has low-level inflammation in the brain. We are working on several solutions to that problem, using neuroimaging techniques such as diffusion tensor imaging, positron emission tomography, and magnetic resonance spectroscopy. We hope to make a safe, non-invasive and accurate test available for neuroinflammation. For these studies, we are currently recruiting people with chronic pain and fatigue, rheumatoid arthritis and healthy people.

Exploring the effects of opioid painkillers on the brain

While strong painkillers are important in managing pain, they may cause problems in some individuals when used for a long period of time. Some of those problems include addiction, changes in mood, and even increased sensitivity to pain. We are conducting brain scans on people who are starting or stopping opioid painkillers to determine how the drugs affect the brain and cause problems. With the information we gain, we hope to find ways to improve pain treatments and minimize their unwanted side effects.

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